Application of the sub-classification AGC NOS and AGC FN in Pap Smears AGC: utility in clinical practice: Essay

Abstract

With the use of the pap smear in screening programs there has been a decrease in cervical cancer but the pap
smear is also a tool for early diagnosis of endocervical adenocarcinoma. Endocervical adenocarcinoma is a
delicate disease because, even though it is a rare disease, it is becoming more and more widespread, affecting
young women of childbearing age. Furthermore, it is asymptomatic, hardly visible colposcopically and is also
a dangerous disease whose risk does not diminish after diagnosis of AGC but remains high over time.
The study aims to evaluate the usefulness of the subcategory of the AGC in AGC NOS and AGC FN to assess
whether the use can give advantages in clinical practice
93248 Pap Smears were considered in this study, of which only 50 were suitable for the study (diagnosis of
AGC and histological examination on the endocervix), these were reclassified according to the indications of
Bethesda in AGC NOS and AGC FN
In the reclassified Pap Smears as AGC NOS we obtained, on the histological examination, 79% of lesions of
low clinical-evolutionary impact and only the 21% of lesions with a high clinical-evolutionary impact. on the
other hand, in the reclassified Pap Smears as AGC FN we obtained 23% of lesions of low clinical-evolutionary
impact and the 77% of lesions with a high clinical-evolutionary impact. In addition, in patients over 50 with
the diagnosis of AGC FN, extracervical diseases prevail
The sub-classification in AGC NOS and AGC FN has proved useful to guide the clinician in carrying out more
detailed examinations in women diagnosed with AGC FN and moreover in a patient over 50 years the diagnosis
of AGC FN must orientate the clinician to an extension of the investigations also, and above all, at the level
of the remaining parts of the genital apparatus (in particular the endometrium) or of the neighboring organs
(bladder, rectum).